000			02061 a2200205 4500
020			_a1574444719
020			_a9781574444711
082	0	4	_a615.19 _bHAN
245	0	0	_aHandbook of assay development in drug discovery _cEdited by Lisa K. Minor
260			_aBoca Raton _bCRC Press _c2006
300			_a488p.
500			_aHB
520			_aThe need to screen targets faster and more efficiently, coupled with advances in parallel and multiplex chemical synthesis, has contributed to the increasing use of multiwell assays for drug discovery. The Handbook of Assay Development in Drug Discovery is a reference that describes the complete armament of tools currently available for performing various assay techniques. Featuring contributions from assay developers in the pharmaceutical and vendor communities, the book presents descriptions of methods, laboratory guidelines and protocols used to perform such methods, specific examples of each assay system, and troubleshooting tools. The handbook describes biochemical assay classes as well as non-class specific assay development for cell-based assays. It covers a wide range of target classes—including kinases, proteases, nuclear receptors, and GPCRs—and describes currently employed methods and assay types, such as radioligand binding assays, image analysis assays, enzyme fragment complementation, and bioluminescent and fluorescent-based assays. Designed as a guide to running an assay from start to finish, the Handbook of Assay Development in Drug Discovery is an ideal bench top companion for discovery researchers, laboratory managers, academics, and other scientists involved in drug discovery screening, lead profiling, therapeutic target evaluation, and assay development and implementation in the pharmaceutical and biotechnology industri
546			_aEng
650			_aDrug development-Handbooks, manuals, ect _931352
650			_aDrug-Research-Handbooks,manuals,ect _931353
650			_aDrugs-Design-Handbooks,manuals,ect _931354
700			_aMinor, Lisa (ed.) _931355
942			_cREF
999			_c41229 _d41229